Hayashi Y, Shimizu I, Yoshida Y, Ikegami R, Suda M, Katsuumi G, Fujiki S, Ozaki K, Abe M, Sakimura K, Okuda S, Hayano T, Nakamura K, Walsh K, Jespersen NZ, Nielsen S, Scheele C, Minamino T. Coagulation factors promote brown adipose tissue dysfunction and abnormal systemic metabolism in obesity. iScience. June 2022 Camilla Scheele and Søren Nielsen. Can we target obesity using a single-cell atlas of adipose tissue? Med (N Y). May 2022 Scheele C, Henriksen TI, Nielsen S. Isolation and Characterization of Human Brown Adipocytes. Methods Mol Biol. 2022 O. Sveidahl Johansen, T. Ma, J. B. Hansen, L.K. Markussen, R. Schreiber, L. Reverte-Salisa, H. Dong, D. P. Christensen, W. Sun, T. Gnad, I. Karavaeva, T. S. Nielsen, S. Kooijman, C. Cero, O. Dmytriyeva, Y. Shen, M. Razzoli, S. L. O’Brien, E. N. Kuipers, C. H. Nielsen, W. Orchard, N. Willemsen, N. Z. Jespersen, M. Lundh, E. G. Sustarsic, C. M. Hallgren, M. Frost, S. McGonigle, M. S. Isidor, C. Broholm, O. Pedersen, J. B. Hansen, N. Grarup, T. Hansen, A. Kjær, J. G. Granneman, M. M. Babu, D. Calebiro, S. Nielsen, M. Rydén, R. Soccio, P. C. C. Rensen, J. T. Treebak, T. W. Schwartz, B. Emanuelli, A. Bartolomucci, A. Pfeifer, R. Zechner, C. Scheele, S. Mandrup, Z. Gerhart-Hines. “Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis”. Cell. May 2021. C. Schlein, A. W. Fischer, F. Sass, A. Worthmann, K. Tödter, M. Y. Jaeckstein, J. Behrens, M.D. Lynes, M. A. Kiebish, N. R. Narain, V. Bussberg, A. Darkwah, N. Z. Jespersen, S. Nielsen, C. Scheele, M. Schweizer, I. Braren, A. Bartelt, Y.H. Tseng, J. Heeren, L. Scheja. “Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution”. Cell Rep. 34 (2). Jan. 2021. K. Plucińska, N. Z. Jespersen, E. L. Brown, P.S. Petersen, K. Rupar, S. Nielsen, C. Scheele & B. Emanuelli. “Calsyntenin 3β Is Dynamically Regulated by Temperature in Murine Brown Adipose and Marks Human Multilocular Fat”. Frontiers in Endocrinology, 11, Sep.2020. D.P. Blondin, S. Nielsen, E. N. Kuipers, M. C. Severinsen, V. H. Jensen, S. Miard, N. Z. Jespersen, S. Kooijman, M. R. Boon, M. Fortin, S. Phoenix, F. Frisch, B. Guérin, É. E. Turcotte, F. Haman, D. Richard, F. Picard, P. C. N. Rensen, C. Scheele, and A. C. Carpentier. “Human Brown Adipocyte Thermogenesis Is Driven by Β2-AR Stimulation.” Cell Metabolism vol. 32, no. 2, pp. 287-300. Aug. 2020. K. Van Tran, E. L. Brown, T. DeSouza, N. Z. Jespersen, C. Nandrup-Bus, Q. Yang, Z. Yang, A. Desai, S. Y. Min, R. Rojas-Rodriguez, M. Lundh, A. Feizi, H. Willenbrock, T. J. Larsen, M. C. K. Severinsen, K. Malka, A. M. Mozzicato, A. S. Deshmukh, B. Emanuelli, B. K. Pedersen, T. Fitzgibbons, C. Scheele, S. Corvera, and S. Nielsen, “Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473,” Nat. Metab., vol. 2, no. 5, pp. 397–412, May 2020. A. S. Deshmukh, L. Peijs, J. L. Beaudry, N. Z. Jespersen, C. H. Nielsen, T. Ma, A. D. Brunner, T. J. Larsen, R. Bayarri-Olmos, B. S. Prabhakar, C. Helgstrand, M. C. K. Severinsen, B. Holst, A. Kjaer, M. Tang-Christensen, A. Sanfridson, P. Garred, G. G. Privé, B. K. Pedersen, Z. Gerhart-Hines, S. Nielsen, D. J. Drucker, M. Mann, and C. Scheele, “Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine,” Cell Metab., vol. 30, no. 5, p. 963–975.e7, Nov. 2019. S. Y. Min, A. Desai, Z. Yang, A. Sharma, T. DeSouza, R. M. J. Genga, A. Kucukural, L. M. Lifshitz, S. Nielsen, C. Scheele, R. Maehr, M. Garber, and S. Corvera, “Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells,” Proc. Natl. Acad. Sci. U. S. A., vol. 116, no. 36, pp. 17970–17979, Sep. 2019. J. M. A. de Jong, W. Sun, N. D. Pires, A. Frontini, M. Balaz, N. Z. Jespersen, A. Feizi, K. Petrovic, A. W. Fischer, M. H. Bokhari, T. Niemi, P. Nuutila, S. Cinti, S. Nielsen, C. Scheele, K. Virtanen, B. Cannon, J. Nedergaard, C. Wolfrum, and N. Petrovic, “Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice,” Nat. Metab., vol. 1, no. 8, pp. 830–843, Aug. 2019. N. Z. Jespersen, A. Feizi, E. S. Andersen, S. Heywood, H. B. Hattel, S. Daugaard, L. Peijs, P. Bagi, B. Feldt-Rasmussen, H. S. Schultz, N. S. Hansen, R. Krogh-Madsen, B. K. Pedersen, N. Petrovic, S. Nielsen, and C. Scheele, “Heterogeneity in the perirenal region of humans suggests presence of dormant brown adipose tissue that contains brown fat precursor cells,” Mol. Metab., vol. 24, pp. 30–43, Jun. 2019. R. Ikegami, I. Shimizu, T. Sato, Y. Yoshida, Y. Hayashi, M. Suda, G. Katsuumi, J. Li, T. Wakasugi, Y. Minokoshi, S. Okamoto, E. Hinoi, S. Nielsen, N. Z. Jespersen, C. Scheele, T. Soga, and T. Minamino, “Gamma-Aminobutyric Acid Signaling in Brown Adipose Tissue Promotes Systemic Metabolic Derangement in Obesity,” Cell Rep., vol. 24, no. 11, p. 2827–2837.e5, Sep. 2018. H. Takahashi, C. R. R. Alves, K. I. Stanford, R. J. W. Middelbeek, P. Nigro, R. E. Ryan, R. Xue, M. Sakaguchi, M. D. Lynes, K. So, J. D. Mul, M. Y. Lee, E. Balan, H. Pan, J. M. Dreyfuss, M. F. Hirshman, M. Azhar, J. C. Hannukainen, P. Nuutila, K. K. Kalliokoski, S. Nielsen, B. K. Pedersen, C. R. Kahn, Y. H. Tseng, and L. J. Goodyear, “TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism,” Nat. Metab., vol. 1, no. 2, pp. 291–303, Feb. 2019. E. G. Sustarsic, T. Ma, M. D. Lynes, M. Larsen, I. Karavaeva, J. F. Havelund, C. H. Nielsen, M. P. Jedrychowski, M. Moreno-Torres, M. Lundh, K. Plucinska, N. Z. Jespersen, T. J. Grevengoed, B. Kramar, J. Peics, J. B. Hansen, F. Shamsi, I. Forss, D. Neess, S. Keipert, J. Wang, K. Stohlmann, I. Brandslund, C. Christensen, M. E. Jørgensen, A. Linneberg, O. Pedersen, M. A. Kiebish, K. Qvortrup, X. Han, B. K. Pedersen, M. Jastroch, S. Mandrup, A. Kjær, S. P. Gygi, T. Hansen, M. P. Gillum, N. Grarup, B. Emanuelli, S. Nielsen, C. Scheele, Y. H. Tseng, N. J. Færgeman, and Z. Gerhart-Hines, “Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis,” Cell Metab., vol. 28, no. 1, p. 159–174.e11, Jul. 2018. T. I. Henriksen, S. E. Heywood, N. S. Hansen, B. K. Pedersen, C. C. Scheele, and S. Nielsen, “Single Cell Analysis Identifies the miRNA Expression Profile of a Subpopulation of Muscle Precursor Cells Unique to Humans with Type 2 Diabetes,” Front. Physiol., vol. 9, p. 883, 2018. J. Sanchez-Gurmaches, Y. Tang, N. Z. Jespersen, M. Wallace, C. Martinez Calejman, S. Gujja, H. Li, Y. J. K. Edwards, C. Wolfrum, C. M. Metallo, S. Nielsen, C. Scheele, and D. A. Guertin, “Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis,” Cell Metab., vol. 27, no. 1, p. 195–209.e6, Jan. 2018. T. I. Henriksen, P. K. Davidsen, M. Pedersen, H. S. Schultz, N. S. Hansen, T. J. Larsen, A. Vaag, B. K. Pedersen, S. Nielsen, and C. Scheele, “Dysregulation of a novel miR-23b/27b-p53 axis impairs muscle stem cell differentiation of humans with type 2 diabetes,” Mol. Metab., vol. 6, no. 7, 2017. C. Scheele and S. Nielsen, “Metabolic regulation and the anti-obesity perspectives of human brown fat,” Redox Biology, vol. 12. Elsevier B.V., pp. 770–775, 01-Aug-2017. T. Hvid, T. Akerstrom, S. Nielsen, C. Yfanti, A. Juul, B. Lindegaard, B. K. Pedersen, and P. Hojman, “Pre-training levels of testosterone and sex hormone-binding globulin are not correlated with training adaptations in fat mass and insulin sensitivity in healthy young men,” Endocrine, vol. 52, no. 3. Humana Press Inc., pp. 660–663, 01-Jun-2016. S. Nielsen, T. Åkerström, A. Rinnov, C. Yfanti, C. Scheele, B. K. Pedersen, and M. J. Laye, “The miRNA plasma signature in response to acute aerobic exercise and endurance training,” PLoS One, vol. 9, no. 2, Feb. 2014. S. Nielsen, T. Hvid, M. Kelly, B. Lindegaard, C. Dethlefsen, K. Winding, N. Mathur, C. Scheele, B. K. Pedersen, and M. J. Laye, “Muscle specific miRNAs are induced by testosterone and independently upregulated by age,” Front. Physiol., vol. 4 JAN, 2014. C. Scheele, S. Nielsen, M. Kelly, C. Broholm, A. R. Nielsen, S. Taudorf, M. Pedersen, C. P. Fischer, and B. K. Pedersen, “Satellite Cells Derived from Obese Humans with Type 2 Diabetes and Differentiated into Myocytes In Vitro Exhibit Abnormal Response to IL-6,” PLoS One, vol. 7, no. 6, p. e39657, Jun. 2012. A. Rinnov, C. Yfanti, S. Nielsen, T. C. A. Åkerström, L. Peijs, A. Zankari, C. P. Fischer, and B. K. Pedersen, “Endurance training enhances skeletal muscle interleukin-15 in human male subjects,” Endocrine, vol. 45, no. 2, pp. 271–278, Mar. 2014. C. Scheele, T. J. Larsen, and S. Nielsen, “Novel nuances of human brown fat,” Adipocyte, vol. 3, no. 1, pp. 54–57, Jan. 2014. C. Yfanti, A. R. Nielsen, T. Åkerström, S. Nielsen, A. J. Rose, E. A. Richter, J. Lykkesfeldt, C. P. Fischer, and B. K. Pedersen, “Effect of antioxidant supplementation on insulin sensitivity in response to endurance exercise training,” Am. J. Physiol. Metab., vol. 300, no. 5, pp. E761–E770, May 2011. C. Yfanti, C. P. Fischer, S. Nielsen, T. Åkerström, A. R. Nielsen, A. S. Veskoukis, D. Kouretas, J. Lykkesfeldt, H. Pilegaard, and B. K. Pedersen, “Role of vitamin C and E supplementation on IL-6 in response to training,” J. Appl. Physiol., vol. 112, no. 6, pp. 990–1000, Mar. 2012. S. Nielsen, C. Scheele, C. Yfanti, T. Åkerström, A. R. Nielsen, B. K. Pedersen, and M. Laye, “Muscle specific microRNAs are regulated by endurance exercise in human skeletal muscle,” J. Physiol., vol. 588, no. 20, pp. 4029–4037, Oct. 2010. J. A. Timmons, S. Knudsen, T. Rankinen, L. G. Koch, M. Sarzynski, T. Jensen, P. Keller, C. Scheele, N. B. J. Vollaard, S. Nielsen, T. Akerström, O. A. MacDougald, E. Jansson, P. L. Greenhaff, M. A. Tarnopolsky, L. J. C. Van Loon, B. K. Pedersen, C. J. Sundberg, C. Wahlestedt, S. L. Britton, and C. Bouchard, “Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans,” J. Appl. Physiol., vol. 108, no. 6, pp. 1487–1496, 2010. C. Yfanti, T. Åkerström, Sø. Nielsen, A. R. Nielsen, R. Mounier, O. H. Mortensen, J. Lykkesfeldt, A. J. Rose, C. P. Fischer, and B. K. Pedersen, “Antioxidant supplementation does not alter endurance training adaptation,” Med. Sci. Sports Exerc., vol. 42, no. 7, pp. 1388–1395, Jul. 2010. C. Scheele, S. Nielsen, and B. K. Pedersen, “ROS and myokines promote muscle adaptation to exercise,” Trends Endocrinol. Metab., vol. 20, no. 3, pp. 95–99, Apr. 2009. P. Hojman, M. Pedersen, A. R. Nielsen, R. Krogh-Madsen, C. Yfanti, T. Åkerstrom, S. Nielsen, and B. K. Pedersen, “Fibroblast growth factor-21 is induced in human skeletal muscles by hyperinsulinemia,” Diabetes, vol. 58, no. 12, pp. 2797–2801, Dec. 2009. S. Nielsen and B. K. Pedersen, “Skeletal muscle as an immunogenic organ,” Current Opinion in Pharmacology, vol. 8, no. 3. Curr Opin Pharmacol, pp. 346–351, Jun-2008. O. H. Mortensen, K. Andersen, C. Fischer, A. R. Nielsen, S. Nielsen, T. Åkerström, M. B. Aastrøm, R. Borup, and B. K. Pedersen, “Calprotectin is released from human skeletal muscle tissue during exercise,” J. Physiol., vol. 586, no. 14, pp. 3551–3562, Jul. 2008. C. Broholm, O. H. Mortensen, S. Nielsen, T. Akerstrom, A. Zankari, B. Dahl, and B. K. Pedersen, “Exercise induces expression of leukaemia inhibitory factor in human skeletal muscle.,” J. Physiol., vol. 586, no. 8, pp. 2195–201, Apr. 2008. L. Frydelund-Larsen, M. Penkowa, T. Akerstrom, A. Zankari, S. Nielsen, and B. K. Pedersen, “Exercise induces interleukin-8 receptor (CXCR2) expression in human skeletal muscle,” Exp. Physiol., vol. 92, no. 1, pp. 233–240, 2007. L. Frydelund-Larsen, T. Akerstrom, S. Nielsen, P. Keller, C. Keller, and B. K. Pedersen, “Visfatin mRNA expression in human subcutaneous adipose tissue is regulated by exercise,” Am. J. Physiol. - Endocrinol. Metab., vol. 292, no. 1, Jan. 2007. C. Yfanti, S. Nielsen, C. Scheele, and B. K. Pedersen, “Exercise as a Model to Study Interactions Between Oxidative Stress and Inflammation,” in Studies on Experimental Models, Humana Press, 2011, pp. 521–529.
